The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells

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  • SAITO Yuichi
    Department of Oral Microbiology, School of Dentistry, Tokyo Medical and Dental University Department of Oral Microbiology, School of Dentistry, Niigala University
  • HORIKAWA Takahiro
    Department of Oral Microbiology, School of Dentistry, Tokyo Medical and Dental University Department of Oral Microbiology, School of Dentistry, Niigala University
  • KONDO Wataru
    Department of Oral Microbiology, School of Dentistry, Tokyo Medical and Dental University Department of Oral Microbiology, School of Dentistry, Niigala University

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  • The role complement in immune phagocytosis of group A streptococci by mouse peritoneal phagocytic cells

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The role of complement in ingestion of nonencapsulated virulent group A streptococci by mouse peritoneal phagocytic cells was studied in vitro in the presence of type-specific IgG or IgM anti-M antibody. Type-specific IgG anti-M antibody significantly enhanced the phagocytosis, whereas IgM antibody was less effective in opsonization of the virulent group A streptococci. The extent of phagocytosis of streptococci sensitized with IgG or IgM anti-M antibody was not influenced by the presence of complement. These results suggested that complement was not an essential factor for efficient phagocytosis of virulent group A streptococci.

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