Antiviral Activity of Scillarenin, a Plant Bufadienolide

SATO Norio, MURO Toshio

doi:10.1111/j.1348-0421.1974.tb00832.x

Antiviral Activity of Scillarenin, a Plant Bufadienolide

DOI Web Site Web Site Web Site PubMed 参考文献29件

SATO Norio

Department of Bacteriology, Tohoku University School of Medicine Research Division, Taisho Pharmaceutical Co., Ltd.,
MURO Toshio

Department of Bacteriology, Tohoku University School of Medicine Research Division, Taisho Pharmaceutical Co., Ltd.,

この論文をさがす

抄録

Antiviral activity of scillarenin, a plant bufadienolide, and its mode of action were studied. Scillarenin selectively inhibited replication of picornaviruses, in particular, rhinovirus. At concentrations inhibiting rhinovirus replication, scillarenin had no effect on the synthesis of macromolecules in host cells. The action of scillarenin was not direct inactivation of virus. Scillarenin could inhibit virus replication when given at the latter half of latent period, although this treatment did not interfere with the normal level of viral RNA synthesis. The RNA synthesized in the presence of this compound showed the same sedimentation coefficient as normal viral RNA but possessed a reduced infectivity.