The effect of vitamin B12 administration on Japanese children

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  • THE EFFECT OF VITAMIN B<sub>12</sub> ADMINISTRATION ON JAPANESE CHILDREN

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The studies of the effect of vitamin B12 administration to a large number of Japanese children in different areas were carried out from 1959 to 1961 by the B12 Study Group of the Vitamin B Research Committee of Japan.<br>It was observed that oral administration of 25μg of B12 daily to the children aged 3 to 14 years over a period of one year did not show any definite promoting effect on the growth of the children. However, in the statistical analyses for B12 values of the whole blood, 276-380 children aged 9 to 14 years showed a significant increase in the B12 level when B12 was supplemented for 6 months to one year.<br>The average normal value of B12 in the whole blood of Japanese children aged 9 to 14 years was found to be 0.361mμg (δ=0.135mμg)/ml.<br>As the children in this study were taking daily around 1μg or more of B12 from their diet, the findings mentioned above do not exclude the possibility of growth-promoting effects on children when the intake of the vitamin is not sufficient.

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