Structure and anti-M.leprae activity relationships of new quinolones

DOI PubMed 34 References Open Access
  • GIDOH Masaichi
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases

Bibliographic Information

Other Title
  • ニューキノロン系抗菌薬の構造式と抗らい菌活性の相関

Search this article

Description

Due to the emergence of drug resistant M.leprae , there is a need to look for new drugs for the treatment of leprosy. We evaluated the effectiveness of new quinolones in vitro as well as in vivo. The in vitro and in vivo results suggested that a cyclopropyl group at the 1-position, COOH at the 3-position, OH at the 4-position, NH2 or OH-substitutions at the 5-position, F at the 6-position, 5- and 6-membered rings at the 7-position, halogen (F or Cl) or OCH3 at the 8-position of the quinolone core structure, remarkably enhance ant-M.leprae activities of the drug.

Journal

References(34)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top