Studies on Riboflavin Tetranicotinate

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  • KOTAKI AKIRA
    Institute of Biochemistry, Faculty of Medicine, University of Nagoya
  • YAGI KUNIO
    Institute of Biochemistry, Faculty of Medicine, University of Nagoya

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  • Its synthesis and physicochemical properties
  • I. Its Synthesis and Physicochemical Properties

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Riboflavin 2′, 3′, 4′, 5′-tetranicotinate (m. p. 147-150°) was synthesized by direct acylation of riboflavin with nicotinyl chloride and its chemical and physical properties were reported. Molar extinction coefficients of its benzene solution at 344, 445 and 471mμ were determined to be 8.5×103, 12.5×103 and 9.7×103 cm-1M-1, respectively. Emission maximum of the solution, when excited at 360mμ, was found at 524mμ. This compound was found to be soluble in various organic solvents, such as benzene, chloroform, alcohols, ketones, esters including triglycerides, dioxane and so on. However, its solubility in water (at neutral pH) was somewhat less than that of riboflavin. It showed considerable resistance to photo-decomposition at neutral pH, as compared with free riboflavin.

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