治らい剤の作用機序に関する研究(第4報)

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タイトル別名
  • Studies on the Mode of Action of Antileprous drugs
  • DDS , ソノ カンレン ヤクブツ ノ キンタイ キュウチャク ニ ツイテ
  • DDS,その関連薬物の菌体吸着について
  • IV. Adsorption of DDS and the Relating Drugs on Bacteria

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The adsorption of DDS and the relating drugs on NQ bacilli and E. coli K-12 (CS-2) was examined by Batch Method.<br>The drugs employed were DDS35, DADDS35, DDS•-G, and four of non-labeled sulfaagents. These were separately dissolved into 5ml of calf serum or physiological saline in a concentration of 10μg/ml. The lyophilized bacilli of 15, 30, 60, 120mg each were suspended and centrifuged, after the vigorous agitation followed by 1 or 4 hours' shaking-incubation.<br>As the result, it was found that the adsorption of a drug on bacteria was parallel to a certain extent with the adsorptivity to serum and was also inhibited by the adsorptivity of the calf serum when it was put to use as a basal medium.<br>No influence could be found by the pre-treatment of NQ bacilli with 5% TCA or with ethanol-ether. Therefore, this adsorption is supposed to be merely non-specific one.<br>The adsorption of DDS35 on the coli bacilli was higher than that on NQ bacilli, because the coli bacilli adsorbed DDS35 even in the calf serum. It may perhaps be due to the difference in the form of the bacterial clumps between the two strains.<br>The adsorption on an activated charcoal was superior to that on the two strains.<br>The adsorbed DDS35 per 100mg of NQ bacilli was increased with the weight of NQ bacilli suspended into the saline. While, it was contrary decreased in the case of DADDS35, suggesting the saturation in the earlier stage.<br>When it was used non-labeled Sulfaisoxazole, -dimethoxine, -methoxypyridazine, Sulfonamide, and DDS, a lowering in the optical density could be detected, though not so clearly noticed.<br>Based on this interactive adsorption and on a presumption concerning the more predominant out-flow of labile conjugates from capillary vessels than that of the stable conjugates, the drug action mechanism in the peripheral lesions was mentioned.

収録刊行物

  • レプラ

    レプラ 39 (3-4), 263-267, 1970

    日本ハンセン病学会

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