Effect of Dietary Linoleic,α-Linolenic and Arachidonic Acids on Lipid Metabolism,Tissue Fatty Acid Composition and Eicosanoid Production in Rats

DOI Web Site PubMed オープンアクセス
  • IKEDA Ikuo
    Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture
  • MITSUI Kousuke
    Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture
  • IMAIZUMI Katsumi
    Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture

書誌事項

タイトル別名
  • Effect of Dietary Linoleic, .ALPHA.-Linolenic and Arachidonic Acids on Lipid Metabolism, Tissue Fatty Acid Composition and Eicosanoid Production in Rats.
  • Effect of Dietary Linoleic アルファ Linolen

この論文をさがす

説明

Rats were fed semipurified diets containing 10% fat with a constant polyunsaturated/monounsaturated/saturated fatty acid ratio of 1:1:1. This was performed by mixing vegetable oils. Linoleic acid was the sole polyunsaturated fatty acid in the linoleic acid group. The a-linolenic and arachidonic acids were contained at the 1 % level in the diet at the expense of linoleic acid in the α-linolenic acid and arachidonic acid groups, respectively. The concentration of serum triglyceride, phospholipid and liver triglyceride were significantly lower in the α-linolenic acid and arachidonic acid groups than in the linoleic acid group. Hepatic phospholipids were significantly higher in the α-linolenic acid and arachidonic acid groups as compared to the linoleic acid group. Compared to the linoleic acid group, the percentages of arachidonic acid in the phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in the liver and heart were significantly lower in the α-linolenic acid group; in contrast, they were significantly higher in the arachidonic acid group. Dietary arachidonic acid, but not α-linolenic acid, resulted in a marked reduction of linoleic acid and increased arachidonic and n-6 docosapenta-enoic acids in heart cardiolipin. Platelet thromboxane (TX) A2 production tended to be lower in the α-linolenic acid group as compared to the linoleic acid and arachidonic acid groups. There was no difference in TXA2 production between the linoleic acid and arachidonic acid groups. The aortic production of prostacyclin (PGI2) was the same among the three groups. The ratios of TXA2 and PGI2 in the linoleic acid and arachidonic acid groups were comparable, whereas they were significantly higher than that in the α-linolenic acid group. The results demonstrate that dietary arachidonic acid enriches the arachidonic acid content in tissue phospholipids more effectively than linoleic acid, whereas the effect on the production of TXA2 and PGI2 was comparable under these experimental conditions.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ