Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

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Protein biosynthesis, using 14C-serine and related aspects in pyridoxine deficient rats were studied. The following results were obtained.<br>1. The activities of rat liver succinate dehydrogenase, xanthine oxidase and alanine aminotransferase decreased with the severity of pyridoxine deficiency.<br>2. A reduced incorporation of 14C-serine into protein, in vitro, was observed in the pH-5 enzyme microsomal preparations obtained from pyridoxine deficient rats as compared to the normal controls. This reduction is partially overcome by the subcutaneous injection of pyridoxine to pyridoxine deficient animals two hours prior to killing.<br>3. The pH-5 enzymes were affected to a considerable extent in pyridoxine deficiency.<br>4. The total RNA of the liver decreased while the sRNA was almost unaffected in pyridoxine deficient animals.<br>5. The transfer of aminoacyl-tRNA to microsomes was also affected in pyridoxine deficiency by affecting the soluble transfer enzyme fraction.<br>6. An appreciable decrease in the total liver GSH content was observed in pyridoxine deficient rats.

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