Action of Thiamine Tetrahydrofurfuryl Disulfide on the Isolated Clam Heart

  • 篠崎 英男
    Department of Dermatology, Chiba University School of Medicine Science Section, Takeda Pharmacentical Company, Ltd.

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1. The action of thiamine tetrahydrofurfuryl disulfide (TTFD) on the excised heart of clam (Meretirx meretrix lusoria) was investigated.<br>2. TTFD displayed a striking postive inotropic action. This action did not appear in Ca-free or Na-free solution, but appeared in K-free solution.<br>3. TTFD antagonized the negative inotropic action of acetylcholine.<br>4. These actions of TTFD were closely similar to those of thiamine propyl disulfide and these actions may be ascribed to -N-CHO -C-CH3=C in the structure.

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