The experimental studies on the absorption site and mechanism of tritiated folic acid in rats

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  • 吉野 俊昭
    The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

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  • The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid
  • II. The Experimental Studies on the Absorption Site and Mechanism of Tritiate Folic Acid in Rats

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1. The site and mechanism of folic acid (FA) absorption were studied in the rat, using 3H-FA.<br>2. After intragastric administration of 40μg of 3H-FA per kg of body weight, 79.3 per cent of the administered dose was absorbed from the upper gastrointestinal tract in 6 hours.<br>3. From the jejunal loop, 91.7 per cent of the injected dose was absorbed in 6 hours, and the absorption from the ileum was about 50 per cent of that from the jejunum.<br>4. With the increase of administered doses, the rate of absorption was decreased, while the absolute amount of the absorbed FA increased almost linearly.<br>5. The absorption of FA was not affected by the following conditions: simultaneous administration of Amethopterin or dinitrophenol, pretreatment with Amethopterin or FA, and deficiency of FA.<br>6. The site and mechanism of FA absorption were discussed and a passive transport for FA was suggested.

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