[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Guideline for the Treatment of Leprosy by New Quinolones

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  • ニューキノロン使用指針

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Abstract

Ofloxacin(OFLX) is often applied today as a substitution drug of MDT for drug resistance to dapsone, rifampicin or clofazimine. However, OFLX resistance is also becoming a great concern. Low and/or irregular administration are considered to be the major causes of OFLX resistance. OFLX should be used as a combined therapy, and minimal daily dose of 400mg of OFLX or 200 ?? 300mg of levofloxacin is required. Quinolone resistance should be considered when no improvement of clinical and/or bacterial index is observed after the treatment for 6 months. In such cases, resistance gene detection is necessary.

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