CHANGE IN BLOOD LEVEL OF PANTOTHENIC ACID IN CHILDHOOD AND PANTOTHENIC ACID AND COENZYME A CONTENTS IN RAT LIVER WITH GROWTH

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  • 中村 恒男
    Department of Pediatrics, Kyoto Prefectural University of Medicine
  • 楠 智一
    Department of Pediatrics, Kyoto Prefectural University of Medicine
  • 片岡 季久
    Department of Pediatrics, Kyoto Prefectural University of Medicine
  • 曽山 浩吉
    Department of Pediatrics, Kyoto Prefectural University of Medicine
  • 馬杉 矣三
    Department of Pediatrics, Kyoto Prefectural University of Medicine
  • 田中 健治
    Department of Pediatrics, Kyoto Prefectural University of Medicine

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1. The hepatic CoA value determined by Wakil's sobyl-CoA method was about a half of the value obtained by Kaplan-Lipmann's sulfanilamide method which is sensitive to phosphopantetheine and dephospho-CoA. In addition, the former corresponded to about a half of the total PaA value. From this fact it is suggested that a fair amount of bound pantothenic acid exists in the liver of rats as forms other than CoA.<br>2. The high value of pantothenic acid was obtained in the blood of cord and newborn infant and the value fell as the age advanced. The proportion of the free to the total pantothenic acid was greater in the lower age group. The amount of urinary pantothenic acid excretion showed a reverse relationship and the younger age group tended to show the lower excretion.<br>3. The total hepatic CoA in rats was markedly increased with the growth and the amount of CoA per unit of weight was also increased until 30 days. Thereafter, the value reached a constant level. The total amount of kidney CoA was increased with the growth but the value per unit of weight reached a constant level 10 days after birth. In the brain, both the total amount and the value of CoA per unit of weight reached a constant level 20 days after birth.<br>4. The changes of total pantothenic acid in liver, kidney and brain with the growth of rats showed the same tendencies with those of CoA. The kidney showed a presence of relatively high proportion of free PaA as compared with other organs.

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