Soy Isoflavone Supplementation Alleviates Oxidative Stress and Improves Systolic Blood Pressure in Male Spontaneously Hypertensive Rats
-
- PARK Eunju
- Department of Food and Nutrition, Kyungnam University
-
- SHIN Jang-In
- Department of Food and Nutrition, Hannam University
-
- PARK Ock-Jin
- Department of Food and Nutrition, Hannam University
-
- KANG Myung-Hee
- Department of Food and Nutrition, Hannam University
この論文をさがす
抄録
The aim of this study was to investigate the protective effect of Isoflavone against hypertension, via the mitigation of oxidative stress and prevention of nitric oxide (NO, a potent vasodilator) reduction, in spontaneously hypertensive rats (SHR). The 8 wkold male SHR were divided into two groups, and fed a casein-based high fat diet (120g fat, 1 g cholesterol/kg diet) for 30 d, either with or without 10 g of soy powder (containing 31.2% of Isoflavones)/kg. During the 30-d study period, tail systolic blood pressures (BP) in the control SHR group increased, from 162.4±2.3 to 177, 9±5.4 mmHg (p<0.05), while the Isoflavone-supplemented group benefited from a clear antihypertensive effect (160.1±1.8 to 160.2±4.9mmHg). The serum NO and total radical trapping antioxidant potential (TRAP) were elevated in the Isoflavone group. The isoflavone group also experienced a significant decrease in oxidative DNA damage in leukocytes, using comet assay. DNA damage correlated positively with incremental BP during the study, and systolic BP at the end of the study (p<0.01). Our results indicate that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR.
収録刊行物
-
- Journal of Nutritional Science and Vitaminology
-
Journal of Nutritional Science and Vitaminology 51 (4), 254-259, 2005
一般財団法人 学会誌刊行センター
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681300584960
-
- NII論文ID
- 110002704072
-
- NII書誌ID
- AA00703822
-
- COI
- 1:CAS:528:DC%2BD2MXhtVSktLzF
-
- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
-
- NDL書誌ID
- 7413016
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可