The Improvement of Sleep by Oral Intake of GABA and <i>Apocynum venetum</i> Leaf Extract
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- YAMATSU Atsushi
- Pharma Foods International Co., Ltd.
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- YAMASHITA Yusuke
- Pharma Foods International Co., Ltd.
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- MARU Isafumi
- Pharma Foods International Co., Ltd.
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- YANG Jinwei
- Tokiwa Phytochemical Co., Ltd.
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- TATSUZAKI Jin
- Tokiwa Phytochemical Co., Ltd.
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- KIM Mujo
- Pharma Foods International Co., Ltd.
Bibliographic Information
- Other Title
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- The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract
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Abstract
The effects of two food materials, γ-aminobutyric acid (GABA) produced by natural fermentation and Apocynum venetum leaf extract (AVLE), on the improvement of sleep were investigated in humans. The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and AVLE (50 mg) had beneficial effects on sleep. GABA shortened sleep latency by 5.3 min and AVLE increased non-rapid eye movement (REM) sleep time by 7.6%. Simultaneous intake of GABA and AVLE shortened sleep latency by 4.3 min and increased non-REM sleep time by 5.1%. The result of questionnaires showed that GABA and AVLE enabled subjects to realize the effects on sleep. These results mean that GABA can help people to fall asleep quickly, AVLE induces deep sleep, and they function complementarily with simultaneous intake. Since both GABA and AVLE are materials of foods and have been ingested for a long time, they can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 61 (2), 182-187, 2015
Center for Academic Publications Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681300688640
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- NII Article ID
- 130005074118
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 026378962
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- PubMed
- 26052150
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed