Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of <i>Glechoma hederacea</i> var.<i> </i><i>grandis </i>Leaves (Kakidoushi-Cha)
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- MASUDA Akiko
- Faculty of Human Life Science, Shikoku University
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- TAKAHASHI Chizuru
- Graduate School of Integrated Arts and Sciences, University of Tokushima
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- INAI Miyuki
- Graduate School of Integrated Arts and Sciences, University of Tokushima
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- MIURA Yukari
- Graduate School of Integrated Arts and Sciences, University of Tokushima
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- MASUDA Toshiya
- Graduate School of Integrated Arts and Sciences, University of Tokushima
Bibliographic Information
- Other Title
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- Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of Glechoma hederacea var. grandis Leaves (Kakidoushi-Cha)
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Abstract
In this study, chemical evidence for the potent xanthine oxidase inhibitory activity of “kakidoushi-cha” (dry leaves of Glechoma hederacea var. grandis), a traditional folk tea consumed in Japan, was clarified on the basis of structure identification of the active constituents. Assay-guided fractionation and purification afforded 15 compounds from the most active chromatographic fraction of an extract of the tea. Two flavonoids, apigenin and luteolin, showed remarkable inhibitory activity against xanthine oxidase (XO). The contribution of these flavonoid constituents to the observed XO inhibitory activity of the methanol and boiling-water extracts of the tea was estimated to be ca. 35% and ca. 18%, respectively.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 59 (6), 570-575, 2013
Center for Academic Publications Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681300696320
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- NII Article ID
- 130003393756
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC2cXktlymtw%3D%3D
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 025136366
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- PubMed
- 24477256
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed