Influence of Cigarette Smoke on the L-Ascorbic Acid Metabolism and the Activities of Drug-Metabolizing Enzyme in Rats

  • SUZUKI Emiko
    Department of Nutrition and Food Sciences, Ochanomizu University
  • HAYASHI Mizuki
    Institute of Environmental Science for Human Life, Ochanomizu University
  • KAMINAO Mami
    Institute of Environmental Science for Human Life, Ochanomizu University
  • KURATA Tadao
    Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences

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This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.

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