Influence of Cigarette Smoke on the L-Ascorbic Acid Metabolism and the Activities of Drug-Metabolizing Enzyme in Rats
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- SUZUKI Emiko
- Department of Nutrition and Food Sciences, Ochanomizu University
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- HAYASHI Mizuki
- Institute of Environmental Science for Human Life, Ochanomizu University
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- KAMINAO Mami
- Institute of Environmental Science for Human Life, Ochanomizu University
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- KURATA Tadao
- Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences
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説明
This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 51 (5), 374-376, 2005
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詳細情報 詳細情報について
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- CRID
- 1390282681300934784
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- NII論文ID
- 110002704090
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- HANDLE
- 10083/33570
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- NDL書誌ID
- 7681153
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可