Retinol Status and Expression of Retinol-Related Proteins in Methionine-Choline Deficient Rats
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- MIYAZAKI Hiroshi
- Department of Pediatrics, Osaka Medical College Department of Pediatrics, Osaka Rosai Hospital
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- TAKITANI Kimitaka
- Department of Pediatrics, Osaka Medical College
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- KOH Maki
- Department of Pediatrics, Osaka Medical College
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- INOUE Akiko
- Department of Pediatrics, Osaka Medical College
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- KISHI Kanta
- Department of Pediatrics, Osaka Medical College
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- TAMAI Hiroshi
- Department of Pediatrics, Osaka Medical College
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説明
Retinol and its derivative, retinoic acid, have pleiotropic functions including vision, immunity, hematopoiesis, reproduction, cell differentiation/growth, and development. Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in developed countries and encompasses a broad spectrum of forms, ranging from steatosis to steatohepatitis, which develops further to cirrhosis. Retinol status has an important role in liver homeostasis. The purpose of this study was to evaluate the retinol status and expression of retinol-related proteins, including enzymes and binding proteins, in methionine-choline deficient (MCD) rats as a model of NAFLD. We examined retinol levels in the plasma and liver and gene expression for β-carotene 15,15′-monooxygenase (BCMO), lecithIn: retinol acyltransferase (LRAT), aldehyde dehydrogenase 1A1 (ALDH1A1), ALDH1A2, and cellular retinol binding protein (CRBP)-I in MCD rats. The plasma retinol levels in MCD rats were lower than those in the controls, whereas hepatic retinol levels in MCD rats were higher. BCMO expression in the intestine and liver in MCD rats was lower, whereas that in the testes and the kidneys was higher than in control rats. Expression of LRAT, CRBP-I, ALDH1A1, and ALDH1A2 in the liver of MCD rats was also higher. Altered expression of retinol-related proteins may affect retinol status in NAFLD.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 60 (2), 78-85, 2014
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詳細情報 詳細情報について
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- CRID
- 1390282681301588352
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- NII論文ID
- 130004491369
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC2cXotVSnsrw%3D
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 025440259
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- PubMed
- 24975216
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可