Anti-riboflavin activity of 8-O-alkyl derivatives of riboflavin in some gram-positive bacteria.
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- KASAI Sabu
- Division of Biology, Research Institute for Atomic Energy, Osaka City University
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- YAMANAKA Shigeko
- Division of Biology, Research Institute for Atomic Energy, Osaka City University
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- WANG Shiu-Chuan
- Division of Biology, Research Institute for Atomic Energy, Osaka City University
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- MATSUI Kunio
- Division of Biology, Research Institute for Atomic Energy, Osaka City University
Bibliographic Information
- Other Title
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- Anti Riboflavin Activity of 8 O Alkyl D
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Abstract
Two new 8-O-alkyl derivatives of riboflavin (RF), i.e., 8-methoxy- (MOF), and 8-ethoxy-8-demethyl-D-riboflavin (EOF), their tetraacetate, and the tetraacetate of 8-hydroxy-8-demethyl-D-riboflavin (HOF) were synthesized. The anti-RF activity of MOF, EOF and HOF was estimated from the ratio CR/CI, where CI is the concentration of test flavin added to the culture medium and CR is the minimum concentration of RF needed to restore the growth inhibition. Their activity was also compared with that of roseoflavin (RoF). The decreasing order of anti-RF activity was as follows: MOF>RoF>EOF in Sarcina lutea; RoF>MOF>EOF in Bacillus cereus and Staphylococcus aureus. HOF showed no activity in any of the bacteria tested. The redox potential of these compounds decreases as follows: RF>RoF>EOF>MOF>HOF, and the anti-RF activity of MOF and EOF could be explained by the redox potential difference between these compounds and RF.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 25 (4), 289-298, 1979
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390282681301788544
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- NII Article ID
- 130001371957
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DyaL3cXhtVCqsbo%3D
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 2092481
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed