Insulin resistance in SHR/NDmc-cp rats correlates with enlarged perivascular adipcytes and endothelial cell dysfunction in skeletal muscle

DOI Web Site PubMed 被引用文献2件 参考文献34件 オープンアクセス
  • HARIYA Natsuyo
    Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • MOCHIZUKI Kazuki
    School of Food and Nutritional Sciences, University of Shizuoka Laboratory of Food and Nutritional Sciences, Department of Local Produce and Food Sciences, Faculty of Life and Environmental Sciences, University of Yamanashi
  • INOUE Seiya
    School of Food and Nutritional Sciences, University of Shizuoka
  • MORIOKA Kosuke
    School of Food and Nutritional Sciences, University of Shizuoka
  • SHIMADA Masaya
    School of Food and Nutritional Sciences, University of Shizuoka
  • OKUDA Tohru
    The Institute of Enology and Viticulture, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • GODA Toshinao
    School of Food and Nutritional Sciences, University of Shizuoka

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  • Insulin Resistance in SHR/NDmc-cp Rats Correlates with Enlarged Perivascular Adipocytes and Endothelial Cell Dysfunction in Skeletal Muscle

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説明

Ectopic adipose tissue in skeletal muscle is implicated in the development of insulin resistance, which is frequently induced by abnormal dietary habits such as excessive eating and a high-fat diet. However, the characteristics of ectopic adipocytes are unknown. In this study, we investigated the characteristics of ectopic adipocytes in the skeletal muscle of spontaneously hypertensive corpulent congenic (SHR/NDmc-cp) rats as a model of insulin resistance from excessive eating. SHR/NDmc-cp rats displayed overt insulin resistance with high plasma glucose, insulin, and triacylglycerol concentrations relative to control Wistar-Kyoto (WKY) rats. In contrast, streptozotocin (STZ)-treated WKY rats had high glucose but low insulin concentrations. Ectopic adipocytes were found around blood vessels in the gastrocnemius in SHR/NDmc-cp rats. Areas of perivascular adipocytes and protein expression of resistin were greater in SHR/NDmc-cp rats than in control and STZ-treated WKY rats. The level of the phosphorylated (active) form of endothelial nitric oxide synthase in the gastrocnemius was lower in SHR/NDmc-cp rats than in the other groups. Insulin-resistant SHR/NDmc-cp rats showed enlarged perivascular adipocytes and greater endothelial cell dysfunction in the gastrocnemius.

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