Influence of Treatment with Extracts of Hypsyzigus marmoreus Mushroom on Body Composition during Obesity Development in KK-A[y] Mice

DOI Web Site PubMed 参考文献15件 オープンアクセス
  • IUCHI Takujiro
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital
  • HOSAKA Toshio
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital Third Department of Internal Medicine, Kyorin University School of Medicine
  • SHIROISHI Masahiro
    Agricultural Technology Institute of Nagano Farmers’ Federation
  • ONO Hiraku
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital
  • INUKAI Kouichi
    Third Department of Internal Medicine, Kyorin University School of Medicine
  • SUMITA Takashi
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital
  • SAKAI Gouta
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital
  • KATAYAMA Shigehiro
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital
  • AWATA Takuya
    Department of Endocrinology and Diabetes, Saitama Medical University Hospital

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タイトル別名
  • Influence of Treatment with Extracts of <i>Hypsyzigus marmoreus</i> Mushroom on Body Composition during Obesity Development in KK-A<sup>y</sup> Mice

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抄録

Hypsyzigus marmoreus (HM), an edible mushroom, has several effects, including antitumor, antioxidant and anti-allergy properties. On the other hand, the possibly useful effect of HM in diabetic mice has not as yet been elucidated. In this study, we showed treatment with a water soluble extract from HM (EHM) to reduce fat deposits without affecting body weight loss in KK-Ay mice. EHM treatment also abolished the expressions of pro-inflammatory adipokines, such as tumor necrosis factor α and monocyte chemoattractant protein 1, as compared with vehicle treatment. The expressions of uncoupling protein 3 and peroxisome proliferator-activated receptor gamma coactivator 1α in the soleus muscles of EHM treatment groups were significantly elevated as compared to those in vehicle-treated muscle tissues. These results raise the possibility that EHM can regulate both obesity and insulin resistance.

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