A Long-Term High-Fat Diet Changes Iron Distribution in the Body, Increasing Iron Accumulation Specifically in the Mouse Spleen

DOI Web Site PubMed 2 Citations 19 References Open Access
  • YAMANO Noriko
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • IKEDA Yasumasa
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • SAKAMA Minoru
    Department of Radiological Science, Institute of Health Biosciences, The University of Tokushima Graduate School
  • IZAWA-ISHIZAWA Yuki
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • KIHIRA Yoshitaka
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • ISHIZAWA Keisuke
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • MIYAMOTO Licht
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TOMITA Shuhei
    Division of Molecular Pharmacology, Faculty of Medicine, Tottori University
  • TSUCHIYA Koichiro
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TAMAKI Toshiaki
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School

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Although iron is an essential trace metal, its presence in excess causes oxidative stress in the human body. Recent studies have indicated that iron storage is a risk factor for type 2 diabetes mellitus. Dietary iron restriction or iron chelation ameliorates symptoms of type 2 diabetes in mouse models. However, whether iron content in the body changes with the development of diabetes is unknown. Here, we investigated the dynamics of iron accumulation and changes in iron absorption-related genes in mice that developed obesity and diabetes by consuming a high-fat diet (HFD-fed mice). HFD-fed mice (18-20 wk) were compared with control mice for hematologic features, serum ferritin levels, and iron contents in the gastrocnemius muscle, heart, epididymal fat, testis, liver, duodenum, and spleen. In addition, the spleen was examined histologically. Iron absorption-related gene expression in the liver and duodenum was also examined. Hemoglobin and serum ferritin levels were increased in HFD-fed mice. The HFD-fed mice showed iron accumulation in the spleen, but not in the heart or liver. Increased percentages of the splenic red pulp and macrophages were observed in HFD-fed mice and iron accumulation in the spleen was found mainly in the splenic red pulp. The HFD-fed mice also showed decreased iron content in the duodenum. The mRNA expression of divalent metal transporter-1 (DMT-1), an iron absorption-related gene, was elevated in the duodenum of HFD-fed mice. These results indicate that iron accumulation (specifically accumulation in the spleen) is enhanced by the development of type 2 diabetes induced by HFD.

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