Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency : A Double-Blind, 3-Way Crossover Study
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- SUNAGAWA Yoichi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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- HIRANO Sae
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka Saiseikai General Hospital
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- KATANASAKA Yasufumi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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- MIYAZAKI Yusuke
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- FUNAMOTO Masafumi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- OKAMURA Nobuko
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- HOJO Yuya
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- SUZUKI Hidetoshi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- DOI Osamu
- Shizuoka General Hospital
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- YOKOJI Tsunehiro
- Shizuoka General Hospital
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- MORIMOTO Eriko
- Shizuoka General Hospital
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- TAKAHASHI Tsukasa
- Theravalues Corporation
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- OZAWA Hitomi
- Theravalues Corporation
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- IMAIZUMI Atsushi
- Theravalues Corporation
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- UENO Morio
- Department of Ophthalmology, Kyoto Prefectural University of Medicine
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- KAKEYA Hideaki
- Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
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- SHIMATSU Akira
- Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
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- WADA Hiromichi
- Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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- HASEGAWA Koji
- Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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- MORIMOTO Tatsuya
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization
書誌事項
- タイトル別名
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- Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—
- Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—
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抄録
Curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. To overcome this problem, several curcumin preparations with a drug-delivery system (DDS) have been developed to increase the bioavailability of curcumin after oral administration, and tested as functional foods and potential medical agents in humans. We have also produced capsules containing Theracurmin, curcumin dispersed with colloidal submicron-particles. To evaluate the absorption efficiency of three types of DDS curcumin, we performed a double-blind, 3-way crossover study. We compared plasma curcumin levels after the administration of Theracurmin and 2 other capsule types of curcumin with DDS, BCM-95 (micronized curcumin with turmeric essential oils) and Meriva (curcumin-phospholipid). Nine healthy subjects (male/female=5/4, age: 24-32 y old) were administered these 3 preparations of DDS curcumin, at commonly used dosages. Six capsules of Theracurmin, 1 capsule of BCM-95, and 2 capsules of Meriva contain 182.4±1.0, 279.3±10.7, and 152.5±20.3 mg of curcumin, respectively. The maximal plasma curcumin concentration (0-24 h) of Theracurmin was 10.7 to 5.6 times higher than those of BCM-95 and Meriva, respectively. Moreover, the area under the blood concentration-time curve at 0-24 h was found to be 11.0- and 4.6-fold higher with Theracurmin than BCM-95 and Meriva, respectively. These data indicate that Theracurmin exhibits a much higher absorption efficiency than other curcumin DDS preparations.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 61 (1), 37-44, 2015
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詳細情報 詳細情報について
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- CRID
- 1390282681302015872
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- NII論文ID
- 130005070831
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 026193473
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- PubMed
- 25994138
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可