Vitamin B6 Status of Breast-Fed Infants in Relation to Pyridoxine HCl Supplementation of Mothers.

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The vitamin B6 nutritue of breast-fed infants was evaluated by vitamin B6 intake, plasma pyridoxal 5'-phosphate (PLP) concentration, and growth patterns during the infants' first 6 mo of age. Vitamin B6 intakes of 47 healthy, term infants were significantly correlated with four levels of maternal vitamin B6 supplements: 2.5, 4.0, 7.5, or 10.0mg pyridoxine (PN)⋅HCl/d and met the B6 Adequate Intake (AI, 1998) of 0.1mg/d for infants 0 to 6mo. Only infants whose mothers received 10.0mg PN⋅HCl/d exceeded or met the Recommended Dietary Allowances (RDA, 1989) of 0.3mg vitamin B6/d from 4 to 6mo of age. Plasma PLP concentrations of infants, measured at 1, 4, and 6mo of age paralleled their mother's vitamin B6 intake. Most infants showed normal growth. The findings indicated that a maternal PN⋅HCl supplement of 2.5mg/d provided an adequate amount of vitamin B6 in breast milk (0.15mg/d) for the vitamin B6 status parameters and the growth of breast-fed infants.

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