Dietary 5-Campestenone (Campest-5-en-3-one) Enhances Fatty Acid Oxidation in Perfused Rat Liver
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- TAMARU Shizuka
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- SUZUKI Yo
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- SAKONO Masanobu
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- FUKUDA Nobuhiro
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- IKEDA Ikuo
- Graduate School of Agricultural Science, Tohoku University
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- KONNO Rie
- Technoflora Co. and Synthetic Organic Chemistry Laboratory, RIKEN
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- SHIMIZU Takeshi
- Technoflora Co. and Synthetic Organic Chemistry Laboratory, RIKEN
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- SUZUKI Kunio
- Technoflora Co. and Synthetic Organic Chemistry Laboratory, RIKEN
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Description
The effect of dietary 5-campestenone (campest-5-en-3-one), a chemical modification product of a naturally-occurring plant sterol, campesterol, on lipid metabolism was examined using a rat liver perfusion system. Male Sprague-Dawley rats weighing about 140 g were fed a diet supplemented with or without 0.2% 5-campestenone for 14 d. 5-Campestenone feeding resulted in a marked reduction in the concentrations of serum lipids, such as triacylglycerol (TG), cholesterol, phospholipid, and free fatty acid, without influencing food intake or growth. Then, isolated livers from both groups were perfused for 4 h in the presence of an exogenous linoelaidic acid substrate. Dietary 5-campestenone markedly elevated hepatic ketone body production, while cumulative secretions of TG, cholesterol, and phospholipid by the livers of rats fed 5-campestenone were all significantly lowered as compared to those fed without the compound; the extent of the reduction was more prominent in the secretion of TG than other lipid components. In addition, the reduction of TG secretion was concomitantly accompanied by the reduced incorporation of both exogenous and endogenous fatty acids into this lipid molecule. These results suggest that dietary 5-campestenone exerts its hypotriglyceridemic effect, at least, in part through an enhanced metabolism of endogenous and exogenous fatty acids to oxidation at the expense of esterification in rat liver.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 52 (2), 127-133, 2006
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390282681302161280
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- NII Article ID
- 110004718471
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD28Xlt1Squrg%3D
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- ISSN
- 18817742
- 03014800
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- HANDLE
- 10458/3524
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- NDL BIB ID
- 7899848
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- PubMed
- 16802693
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- IRDB
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed