Intragastric Administration of Allyl Isothiocyanate Reduces Hyperglycemia in Intraperitoneal Glucose Tolerance Test (IPGTT) by Enhancing Blood Glucose Consumption in Mice

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  • MORI Noriyuki
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University Nutrition Sciences, School of Human Culture, University of Shiga Prefecture
  • KURATA Manami
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • YAMAZAKI Hanae
    Laboratory of Ajinomoto Integrative Research for Advanced Dieting, Graduate School of Agriculture, Kyoto University
  • HOSOKAWA Hiroshi
    Division of Biological Information, Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University
  • NADAMOTO Tomonori
    Nutrition Sciences, School of Human Culture, University of Shiga Prefecture
  • INOUE Kazuo
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • FUSHIKI Tohru
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

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We investigated the effects of allyl isothiocyanate (AITC) on the blood glucose levels of mice using an intraperitoneal glucose tolerance test. The intragastric administration of 25 mg/kg body weight AITC reduced the increase in blood glucose level after 2 g/kg body weight glucose was given intraperitoneally, compared with that of control mice. To elucidate the mechanism responsible for the reduction, respiratory gas analysis employing 13C-labeled glucose was performed. The intragastrically administering AITC increased 13CO2 emission, compared to vehicle, after intraperitoneal administration of 13C-labeled glucose. This indicated that AITC increased the utilization of exogenously administered glucose, which was excessive glucose in the blood. To examine whether transient receptor potential (TRP) channels mediated this reduction in the blood glucose levels, we used TRPA1 and TRPV1 knockout (KO) mice. Intragastrically administering AITC reduced the increase in the blood glucose level in TRPA1 KO mice but not in TRPV1 KO mice. These findings suggest that dietary AITC might reduce the increases in blood glucose levels by increasing the utilization of excessive glucose in the blood by activating TRPV1.

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