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- SAKAI Akihiro
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
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- KITA Makoto
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
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- TANI Yoshiki
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
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説明
This review is the current summary of vitamin B6 (B6) biosynthesis in Escherichic coli and other microorganisms. The de novo biosynthesis of B6 has been studied extensively for last three decades. However, the de novo biosynthesis of B6 still remains unclear in spite of its simple structure. For the first two decades, B6 biosynthesis had been mainly studied with E. coil using genetic, nutriticnal, and isotopic labeling experiments. According to these studies, some compounds including glycolaldehyde were identified as the precursor. During the last decade, gene manipulate techniques were rapidly developed, and complete genome sequences of some microorganisms became available. Using these new tools, valuable information has been provided. The complete DNA sequence of pdx genes and other genes, which are possibly involved in B6 biosynthesis, were shown. The roles of some genes and precursors were proposed. Besides K coil, B6 biosynthesis in other microorganisms has been also studied. In some microorganisms, snz/sno was reported to be involved in B6 bio-synthesis. Intriguingly, these genes show no similarity to any of the E. coil pdx genes, and are not found in E. coil. Microorganisms having snz/sno gene homologues lack homologues to pdxA/pdxJ genes, whereas those with homologues to pdxA/pdxJ lack snz/sno gene homologues. Therefore, it is most likely that there are at least two kinds of B6 biosynthetic pathways in microorganisms. These studies provided important clues of B6 biosynthesis, but the entire picture of the B6 biosynthetic pathway remains unclear.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 50 (2), 69-77, 2004
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390282681302201984
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- NII論文ID
- 110002703968
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2cXjvFerurg%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 6931539
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可