The Effects of Bitter Melon (Momordica charantia) Extracts on Serum and Liver Lipid Parameters in Hamsters Fed Cholesterol-Free and Cholesterol-Enriched Diets
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- SENANAYAKE Gamarallage V. K.
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- MARUYAMA Mitsuru
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- SAKONO Masanobu
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- FUKUDA Nobuhiro
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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- MORISHITA Toshiro
- Miyazaki Prefectural Food Development Center
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- YUKIZAKI Chizuko
- Miyazaki Prefectural Food Development Center
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- KAWANO Mikio
- Miyazaki Prefectural Food Development Center
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- OHTA Hideaki
- Faculty of Nutritional Science, Nakanmra Gakuen University
書誌事項
- タイトル別名
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- Effects of Bitter Melon Momordica charantia Extracts on Serum and Liver Lipid Parameters in Hamsters Fed Cholesterol Free and Cholesterol Enriched Diets
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説明
The hypolipidemic effect of dietary methanol fraction (BMMF) extracted from bitter melon (Koimidori variety), at the levels of 05% and 1.0%, was examined in male golden Syrian hamsters fed diets supplemented with and without cholesterol. The feeding of BMMF at 0.5% and 1.0% levels in the diets for 4 wk tended to reduce food intake and growth, although there was no difference in food efficiency (weight gain/food intake). An effect of dietary BMMF on serum triglyceride was not seen in hamsters fed diets free of cholesterol, while hypertriglyceridemia induced by dietary cholesterol was significantly lowered in a dose-dependent manner in those fed diets containing the BMMF. Serum total cholesterol concentration also tended to decrease in a dose-dependent manner following feeding of increasing amounts of BMMF in the presence and absence of cholesterol in the diet. The effects of dietary BMMF on liver triglyceride and total cholesterol levels were marginal, although dietary cholesterol caused a marked accumulation of these lipid molecules in the liver. These results suggest that the BMMF contains some components that could ameliorate lipid disorders such as hyperlipidemia.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 50 (4), 253-257, 2004
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390282681302314368
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- NII論文ID
- 110002703995
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2cXnsFWqsLo%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 7058063
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可