Effects of Intravenous Amino Acids on Anesthesia-Induced Hypothermia in Ovariectomized Rats
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- ANDO Satoko
- Department of Anesthesiology, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
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- KANAZAWA Masahiro
- Department of Anesthesiology, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
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- TSUDA Michio
- Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
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- SUZUKI Toshiyasu
- Department of Anesthesiology, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
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抄録
A decrease in core temperature during general anesthesia is attenuated by infusion of an intravenous amino acid mixture. The purpose of the present study was to investigate the influence of physical and endocrine changes caused by ovariectomy on the inhibitory effect of amino acid infusion on anesthesia-induced hypothermia. Sprague-Dawley female rats were divided into a sham-operated (Sham) group and an ovariectomized (OVX) group. Saline solution or an amino acid mixture solution was infused for 180 min during sevoflurane anesthesia, and the rectal temperature was measured (4 groups). Intraperitoneal white adipose tissue mass, bilateral gastrocnemius weight and plasma insulin levels were measured. In the Sham rats, no inhibitory effect of the amino acid mixture on anesthesia-induced hypothermia was found, while in the OVX rats, hypothermia was significantly decreased. The intraperitoneal fat weight/body weight ratio was significantly higher in the OVX rats than in the Sham rats, but the gastrocnemius weight/body weight ratio was not significantly different. After amino acid infusion, the plasma insulin level was significantly higher in the OVX rats than in the Sham rats. In conclusion, our findings suggest that, in rats, ovarian function or female hormone affects protein turnover mediated by increase in insulin secretion and, thus, decreases the inhibitory effect of an infusion of amino acid mixture on anesthesia-induced hypothermia.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 58 (2), 143-148, 2012
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詳細情報 詳細情報について
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- CRID
- 1390282681302400640
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- NII論文ID
- 130002103032
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC38XmsFymtLw%3D
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 023599743
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- PubMed
- 22790573
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可