Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in Achilles Tendon
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- MINAGUCHI Jun
- Department of Veterinary Anatomy, School of Veterinary Medicine
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- KOYAMA Yoh-ichi
- Nippi Research Institute of Biomatrix, Nippi Inc.
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- MEGURI Natsuko
- Department of Veterinary Anatomy, School of Veterinary Medicine
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- HOSAKA Yoshinao
- Department of Veterinary Anatomy, School of Veterinary Medicine
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- UEDA Hiromi
- Department of Veterinary Anatomy, School of Veterinary Medicine
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- KUSUBATA Masashi
- Nippi Research Institute of Biomatrix, Nippi Inc.
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- HIROTA Arisa
- Nippi Research Institute of Biomatrix, Nippi Inc.
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- IRIE Shinkichi
- Nippi Research Institute of Biomatrix, Nippi Inc.
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- MAFUNE Naoki
- Department o f Food Science, School of Dairy Science, Rakuno Gakuen University
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- TAKEHANA Kazushige
- Department of Veterinary Anatomy, School of Veterinary Medicine
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In order to investigate whether the oral ingestion of collagen peptide affects the extracellular matrix of tendon, two doses (0.2g/kg and 1.0g/kg body weight) were orally administered daily for 56d to a rabbit, and both the size of collagen fibrils and the amount of glycosaminoglycans in the Achilles tendon were measured in comparison with those in a rabbit fed with a control protein, lactalbumin, or water alone. Ingestion of col-lagen peptide or lactalbumin induced a significant increase in collagen fibril diameter and a decrease in fibril density except for a high dose of lactalbumin compared with the water con-trol. A histogram pattern of fibril diameter in a high dose of collagen peptide showed a peak at 160-180nm, which was not observed in other groups. However the percentage of diam-eters over 200nm was the lowest in this group but highest in the low-dose group of collagen peptide. The mean fibril diameter and mass average diameter of a high dose of collagen pep-tide were significantly smaller than those in a low dose. The amount of dermatan sulphate increased in the high-dose groups, while the amount of hyaluronic acid decreased in rabbits fed with collagen peptide or lactalbumin at either dose. These results suggest that the inges-tion of collagen peptide affects the size of collagen fibrils and composition of glycosaminogly-cans in the Achilles tendon and thus may improve the mechanical properties of the Achilles tendon.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 51 (3), 169-174, 2005
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詳細情報 詳細情報について
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- CRID
- 1390282681302494208
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- NII論文ID
- 110002704058
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2MXmt1yrtr8%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 7348074
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- PubMed
- 16161767
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可