Effects of selenium deficiency on vitamin E metabolism in rats.

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  • FISCHER W. C.
    Department of Agricultural Chemistry Oregon State University Corvallis Ciba-Geigy Corporation, P.O. Box 11422, Greensboro
  • WHANGER P. D.
    Department of Agricultural Chemistry Oregon State University Corvallis

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  • Effects of Selenium Deficiency on Vitam

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The metabolism of radioactive vitamin E in selenium defi-cient rats has been compared to the metabolism of this vitamin in rats supplemented with 0.1 ppm selenium as sodium selenite in the diet. After dosing with tritiated α tocopherol, the plasma level of radioactivity remained elevated through 48 hours in deficient rats. In contrast, a decline to nearly background levels occurred within 12 hours in the sup-plemented rats. The uptake and release of radioactivity in the erythro-cytes and liver were found to be more rapid in deficient rats than in sup-plemented ones. A 65% greater increase in excretion of radioactivity oc-curred in the urine from deficient rats as compared to supplemented ones. These data indicate that vitamin E is metabolized more rapidly in selenium deficient rats than in supplemented ones.

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