Effect of exogenous polyunsaturated fatty acids on lipogenic enzyme activity in rat liver under fixed carbohydrate consumption.

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  • MUTO Yasutoshi
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • SHINOHARA Naomi
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo Indiana University School fo Medicine
  • BANPHOTKASEM Sermsri
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo Department of Pediatrics, Ramathibodi Hospital
  • IITOYO Noriko
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • HOSOYA Norimasa
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo

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  • Effect of exogenous polyunsaturated fat

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Studies were conducted to evaluate specific dampening of hyperlipo-genesis (i.e. enhanced lipogenic enzyme activity of the liver in rats refed a high carbohydrate, fat-free diet: F-diet) by exogenous polyunsaturated fatty acids under fixed carbohydrate consumption.<br> In force-feeding of rats with a linoleate-rich diet (F-diet containing 4.5 safflower oil), the lipogenic enzyme activities; fatty acid synthetase (FAS) and malic enzyme (ME), in the liver supernatantt were found to be significantly lower than those in rats force-fed only an F-diet (p<0.02), under conditions of identical consumption of carbohydrate. Among the various methylesters of unsaturated fatty acids administered by gastric intubation at a dose of 0.3g per 100g body weight, arachidonate was most potent in bringing about a significant reduction of hyper-lipogenesis without seriously affecting food intakes.<br> During the same three-day experimental period, fatty acid GLC spectra in both the liver and plasma lipids reflected the exogenous input of PUFA. Plasma total fatty acid concentration (mainly triglyceride) significantly de-creased in the arachidonate group (p<0.01).

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