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Effects of Eicosapentaenoic Acid Supplementation in the Treatment of Chronic Hepatitis C Patients

  • TOMIOKA Kayoko
    Graduate School of Health and Welfare Okayama Prefectural University
  • KAKIBUCHI Naoko
    Department of Food and Nutrition, Setouchi Junior College
  • MURAKAMI Yasuko
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University
  • KAWAKAMI Takayo
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University
  • TAKAGUCHI Kouichi
    Department of Internal Medicine,Kagawa Prefectural Central Hospital
  • KITA Keiji
    Department of Internal Medicine,Kagawa Prefectural Central Hospital
  • OKITA Misako
    Graduate School of Health and Welfare Okayama Prefectural University Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University

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Abstract

Eicosapentaenoic acid (EPA) has been shown to exert anti-inflammatory actions. To evaluate the effects of EPA on chronic hepatitis C, we administered EPA ethyl ester capsules to patients receiving the combination therapy of interferon αa-2b and ribavirin. EPA (1, 800mg/d) was supplemented in combination with vitamin E (300mg/d) and C (600mg/d) to 5 chronic hepatitis C patients (EPA group). Five patients were administered vitamin E and C but not EPA (control group). Blood samples were obtained before and after 4, 8, 12 and 24 wk of therapy and analyzed for fatty acid compositions of erythrocyte and plasma and serum 8-hydroxy-2'-deoxyguanosine. EPA in erythrocyte membrane rose to 3 fold the basal level in the EPA group, while it decreased significantly in the control group after 24 wk of therapy. Lymphocyte counts in the EPA group increased to 120.8±25.4% after 4 wk of therapy and maintained the basal level throughout therapy, whereas the counts decreased significantly in controls. The serum alanine aminotransferase level was improved significantly in the EPA group. Changes in lymphocyte counts following 24 wk of therapy correlated with the EPA level in erythrocyte. The serum 8-hydroxy-2'-deoxyguanosine level at 24 wk in the EPA group was significantly lower than that in controls. These observations may suggest the beneficial effect of EPA supplementation in the treatment of chronic hepatitis C patients.

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