Inhibition of .BETA.-sitosterol on intestinal cholesterol absorption in rat using in vivo dual isotope ratio method.

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  • SHIDOJI Yoshihiro
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • WATANABE Makoto
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • OKU Tsuneyuki
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • MUTO Yasutoshi
    Department of Medicine, GU u University, School of Medicine
  • HOSOYA Norimasa
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo

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  • Inhibition of β-Sitosterol on Intestinal Cholesterol Absorption in Rat Using In Vivo Dual Isotope Ratio Method
  • Inhibition of ベータ Sitosterol on Intesti
  • Inhibition of β-sitosterol in intestinal cholesterol absorption in rat using in vivo dual isotope ratio method

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The inhibitory effects of β-sitosterol on intestinal cholesterol absorption were studied by means of a dual isotope plasma ratio method (in vivo), which is a new technique for the measurement of cholesterol absorption, as well as a ligated-loop method (in situ). The results obtained were as follows:<br> 1. The absorption of β-sitosterol itself was significantly less than cholesterol. Cholesterol was selectively absorbed from rat intestine.<br> 2. When 100 to 1, 000μg of β-sitosterol were added to the dose solution containing 10μg of cholesterol, cholesterol absorption by the in vivo experiment decreased with the increase of additional β-sitosterol.<br> 3. A similar inhibitory effect of β-sitosterol was observed by the in situ ligated-loop method.<br> These results suggest that β-sitosterol actually inhibits cholesterol absorption in the physiological state of an animal.

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