Vitamin B12 Status and Its Association with Helicobacter pylori Infection in Alcohol Dependent Patients
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- OIJEN Martijn G. H. VAN
- Department of Gastroenterology, University Medical Center St.
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- LAHEIJ Robert J. F.
- Department of Gastroenterology, University Medical Center St.
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- JONG Cor A. J. DE
- Novadic-Network for Addiction Treatment Services/Institute for Scientists-Practitioners in Addiction, University of Nijmegen
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- PETERS Wilbert H. M.
- Department of Gastroenterology, University Medical Center St.
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- JANSEN Jan B. M. J.
- Department of Gastroenterology, University Medical Center St.
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Description
Both infection with Helicobacter pylori and alcohol abuse have been associated with low vitamin B12 serum levels. The interaction between both risk factors is unknown. The aim of this study was to determine whether Helicobacter pylori infection is associated with low vitamin B12 levels in alcohol dependent patients. Blood samples were obtained from adult alcohol dependent patients undergoing detoxification and analyzed for serum vitamin B12 levels. Helicobacter pylori infection was serologically measured. Patient characteristics, medication use and alcohol consumption at admission were assessed by interview. A total of 6 out of 8 9 patients included presented low vitamin B12 levels, all were sub clinical deficient (<250 pmol/L) and none were clinical deficient (<150 pmol/L). Infection with Helicobacter pylori was present in 29% of the patients. The average vitamin B12 levels in Helicobacter pylori seropositive and seronegative patients were 1, 033 pmol/L (SD 741) and 9 71 pmol/L (SD 717), respectively. The relation between Helicobacter pylori infection and vitamin B12 deficiency was not of significance (OR=0.48; 95% CI [0.05-4.32]). In conclusion, Helicobacter pylori infection is not a risk factor for low vitamin B12 levels in alcohol dependent patients.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 50 (5), 305-308, 2004
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390282681303444480
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- NII Article ID
- 110002704005
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 7196953
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed