核移植技術を用いたキメラマウスの作出

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  • Chimaeras obtained by the nuclear transplantation technique in the mouse.
  • カク イショク ギジュツ オ モチイタ キメラマウス ノ サク シュツ

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The present study was undertaken to produce chimaeras by using nuclear transplantation technique in the mouse. The nuclear transplantation was performed between BALB/c×BALB/c embryo (GPI-1, a/a and albino) and F1 (C57BL/6J×CBA) ×CBA embryo (GPI-1, b/b and non-albino) at 2-cell stage.<BR>The results obtained are as follows.<BR>1. The proportion of Fl embryos which received BALB nucleus and developed to blastocyst stage was significantly higher than that of BALB embryos receiving Fl nucleus (62% vs 42%).<BR>2. Chimaeras were obtained after transfer of Fl embryos receiving BALB nucleus to the uterus of recipient CD-1 females (38%). On the other hand, BALB embryos receiving F1 nucleus did not produce chimaeric mice.<BR>3. The results of the analysis of chimaeric state showed that BALB/F1 ratio of coat color patterns almost coincided with GPI-1 a/b ratio in the red blood cells but not in the germ cell line.

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