ストレプトゾトシン(STZ)糖尿病ラットにおける尿酸代謝について STZ投与量および投与後期間の影響
書誌事項
- タイトル別名
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- Uric Acid Metabolism in Streptozotocin (STZ)-Induced Diabetic Rats. Effects of Doses of STZ and Length of Follow-Up Period after STZ Injection.
- ストレプトゾトシン STZ トウニョウビョウ ラット ニ オケル ニョウサン
- -Effects of Doses of STZ and Length of Follow-Up Period after STZ Injection-
- -STZ 投与量および投与後期間の影響-
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説明
To aid to elucidate the mechanism of abnormal uric acid metabolism in streptozotocin (STZ) -induced diabetic rats, we studied the effects of the doses of STZ and the length of follow-up period after STZ injection on the relationship between serum glucose and uric acid concentrations in 36 rats. The results are summarized as follows : <BR>(1) The serum glucose level as well as uric acid concentration was significantly increased in both groups of rats injected 40 mg/kg and 50 mg/kg of STZ.<BR>(2) The increase in serum glucose level was significantly greater in the 50 mg/kg group, while there was no difference in the increase of serum uric acid concentration between the two groups.<BR>(3) On the 14th day after STZ injection, the slope of regression line between the serum glucose level and uric acid concentration was smaller in rats injected 50 mg/kg than in those injected 40 mg/kg. It was also smaller on the 42th day than that on the 14th day in rats injected 40 mg/kg of STZ.<BR>It was suggested that both production and excretion of uric acid were increased in STZ-induced diabetic rats.
収録刊行物
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- 日本家政学会誌
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日本家政学会誌 43 (7), 629-634, 1992
一般社団法人 日本家政学会
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詳細情報 詳細情報について
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- CRID
- 1390282681309441536
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- NII論文ID
- 110003167520
- 130003705545
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- NII書誌ID
- AN10040097
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- ISSN
- 18820352
- 09135227
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- NDL書誌ID
- 3788982
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- ja
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