ストレプトゾトシン（ＳＴＺ）糖尿病ラットにおける尿酸代謝について　ＳＴＺ投与量および投与後期間の影響

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タイトル別名
  • Uric Acid Metabolism in Streptozotocin (STZ)-Induced Diabetic Rats. Effects of Doses of STZ and Length of Follow-Up Period after STZ Injection.
  • ストレプトゾトシン STZ トウニョウビョウ ラット ニ オケル ニョウサン
  • -Effects of Doses of STZ and Length of Follow-Up Period after STZ Injection-
  • -STZ 投与量および投与後期間の影響-

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説明

To aid to elucidate the mechanism of abnormal uric acid metabolism in streptozotocin (STZ) -induced diabetic rats, we studied the effects of the doses of STZ and the length of follow-up period after STZ injection on the relationship between serum glucose and uric acid concentrations in 36 rats. The results are summarized as follows : <BR>(1) The serum glucose level as well as uric acid concentration was significantly increased in both groups of rats injected 40 mg/kg and 50 mg/kg of STZ.<BR>(2) The increase in serum glucose level was significantly greater in the 50 mg/kg group, while there was no difference in the increase of serum uric acid concentration between the two groups.<BR>(3) On the 14th day after STZ injection, the slope of regression line between the serum glucose level and uric acid concentration was smaller in rats injected 50 mg/kg than in those injected 40 mg/kg. It was also smaller on the 42th day than that on the 14th day in rats injected 40 mg/kg of STZ.<BR>It was suggested that both production and excretion of uric acid were increased in STZ-induced diabetic rats.

収録刊行物

  • 日本家政学会誌

    日本家政学会誌 43 (7), 629-634, 1992

    一般社団法人 日本家政学会

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