低カルシウム食で飼育した卵巣摘出ラットの骨密度低下に対するイソフラボンアグリコンを含有する大豆発酵抽出物の予防効果

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  • Preventive Effects of a Fermented Soy Extract Containing Isoflavone Aglycons on Bone Loss in Ovariectomized Rats Fed on a Calcium-Deficient Diet

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A fermented soy extract (FSE) was obtained from soy beans that have been fermented with koji mold. This FSE contained 40% (w/w) isoflavone aglycons such as genistein and daidzein. Its effects on bone loss in ovariectomized (OVX) young (5 w) and old (34 w) rats that were fed on a calcium-deficient diet were tested. FSE was orally administered to both ages of OVX rats for 4 weeks. The femurs of the young rats were significantly reduced in their density and strength (breaking force) in comparison with those of the sham-operated rats. These changes were largely prevented in those rats orally receiving FSE with an isoflavone content of 250, 125 or 62.5 mg/kg/d for 4 weeks and in rats orally receiving genistein (50 mg/kg/d), but not in the daidzein-treated group (50 mg/kg/d). Ovariectomy caused atrophy of the uterus, but the uterus weight of the OVX rats administered with FSE and genistein did not differ significantly from that of the OVX rats. The loss of bone with ovariectomy was prevented by the administration of FSE or genistein, but not of daidzein. We also tested the effect of FSE on the bone loss in aged female rats (34 weeks) whose bones were no longer growing. A decrease in bone density and strength was prevented in aged OVX rats receiving FSE orally for 4 weeks at a dose of 250, 125 or 62.5 mg/kg/d. In conclusion, FSE proved to be effective in preventing bone loss in the old rats. Furthermore, the fact that FSE prevented bone loss in the OVX rats suggested a contribution by genistein but not by daidzein.

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  • 日本家政学会誌

    日本家政学会誌 54 (8), 613-621, 2003

    一般社団法人 日本家政学会

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