妊娠末期のマウスにおけるコロイドカーボンの胎盤への沈着と胎児への移行について

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  • Placental uptake and transfer of colloidal carbon in near term mice
  • ニンシン マッキ ノ マウス ニ オケル コロイド カーボン ノ タイバン エ

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In order to investigate how particulate materials are transferred across the placenta and how they are deposited in the system, colloidal carbon particles were injected into pregnant mice intravenously at the 18-19th day of gestation, and the placenta and fetal membranes were examined by light and electron microscopy.<BR>In the labyrinth of chorioallantoic placenta, all the colloidal corbon particles observed were at-tached on the surface of the first layer of the trophoblast being exposed to the maternal blood space, which suggests that this layer constitutes a barrier to the transport of colloidal carbon from maternal blood to the fetus. While colloidal carbon particles were rarely deposited in trophoblast cells of a labyrinth, a large amount of these particles was deposited in trophoblast cells adhering to the Reich-ert's membrane. Therefore, the trophoblast cells at two different sites may play a different role in exchange of material between the mother and fetus. As a small amount of colloidal carbon particles was found to localize in the Reichert's membrane or parietal endodermal cells 6 to 12 hours after the injection, the result may suggest that these particles had been transferred from maternal blood to the fetal yolk sac cavity. The amount transferred, however, was much smaller than that deposited in trophoblast cells. Therefore, the Reichert's membrane appears to act as a barrier to the passage of colloidal carbon particles from maternal blood to the fetal yolk sac cavity.

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