Evaluation of Plant Oils by Their Suppressive Effects on the Expression of Cyclooxygenase-2
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- HOTTA Mariko
- Department of Food Science and Nutrition, Nara Women's University
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- NAKATA Rieko
- Department of Food Science and Nutrition, Nara Women's University
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- INOUE Hiroyasu
- Department of Food Science and Nutrition, Nara Women's University
Bibliographic Information
- Other Title
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- 誘導型シクロオキシゲナーゼ発現抑制を指標にした植物油の機能性評価
- ユウドウガタ シクロオキシゲナーゼ ハツゲン ヨクセイ オ シヒョウ ニ シタ ショクブツユ ノ キノウセイ ヒョウカ
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Abstract
Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG), is widely accepted as a target for non-steroidal anti-inflammatory drugs (NSAIDs). Recent studies have shown that COX-2 was involved not only in inflammation, but also in tumorigenesis and lifestyle-related diseases. We have been investigating the regulation of the COX-2 gene, and found that several chemicals derived from plants such as resveratrol (grapes) suppressed COX-2 gene expression. In this present study, 21 plant oils were evaluated for their suppressive effect on COX-2 gene expression by using a transient transfection assay of the luciferase reporter vector containing the human COX-2 promoter into arterial endothelial cells. We found that the COX-2 promoter activity was suppressed by origanum (65%), clove (40%), rose (30%), eucalyptus (25%), fennel (22%) and bergamot oils (21%) in descending order, suggesting that these oils function as suppressors of COX-2 gene expression, and that this assay system would be useful to identify novel functional components in food materials.
Journal
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- Journal of Home Economics of Japan
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Journal of Home Economics of Japan 59 (6), 373-378, 2008
The Japan Society of Home Economics
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Details 詳細情報について
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- CRID
- 1390282681311000448
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- NII Article ID
- 110006782724
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- NII Book ID
- AN10040097
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- ISSN
- 18820352
- 09135227
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- NDL BIB ID
- 9526998
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- NDL-Digital
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed