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- HOSHI Masaki
- Research Institute of Life Science, Snow Brand Milk Products, Co., Ltd
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- NINOMIYA Takashi
- Research Institute of Life Science, Snow Brand Milk Products, Co., Ltd
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- YUKI Atsushi
- Research Institute of Life Science, Snow Brand Milk Products, Co., Ltd
Bibliographic Information
- Other Title
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- トランスジェニックマウスλE1A/1におけるmasaicismの遺伝学的解析
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Description
Genetic analysis of DNA integrated into a male founder transgenic mouse, λE1A/1, showed that about a half (44/91) of the progeny in the first generation (G1) were transgenic, and that one-fourth (12/44) of the transgenic mice had copy numbers higher than that of the founder and the rest (32/44) did lower. The ratio of the high copy numbers, the low copy numbers and the negatives was approximately 1:3:4. When G1 transgenic mice were mated with normal mice, both the high and the low copy number mice transmitted their incorporated DNA to about half of the next gen-eration without significant changes of the copy numbers. These results suggested that the founder mouse, λE1A/1, was a mosaic containing two types of transgenic cells which were produced by events at two different cleavage stages after the pronuclear injection.
Journal
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- The Japanese journal of animal reproduction
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The Japanese journal of animal reproduction 35 (1), 50-53, 1989
THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT
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Keywords
Details 詳細情報について
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- CRID
- 1390282681311294208
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- NII Article ID
- 130004214190
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- ISSN
- 03859932
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed