A CASE OF SEIP-LAWRENCE SYNDROME WITH ACANTHOSIS NIGRICANS

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  • ASANO SEIICHI
    Departments of Internal Medicine and Dermatology School of Medicine, Keio University
  • MATSUKI SHUN
    Departments of Internal Medicine and Dermatology School of Medicine, Keio University
  • OZAWA YUKIO
    Departments of Internal Medicine and Dermatology School of Medicine, Keio University
  • SARUTA TAKAO
    Departments of Internal Medicine and Dermatology School of Medicine, Keio University
  • NAGASHIMA MASAJI
    Departments of Internal Medicine and Dermatology School of Medicine, Keio University

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1) A case of Seip-Lawrence syndrome with acanthosis nigricans was presented.<br>2) This case showed loss of subcutaneous fat, increased growth rate with acromegaloid pattern, hepatomegaly (fatty filtration and slight cirrhotic changes in the liver) and acanthosis nigricans, but diabetes mellitus and hyperlipemia were not found.<br>3) Her grotesque appearance failed to respond to 30 mg of prednisolone daily for 30 days except decreased pigmentation.

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