Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary

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  • SHENG Xia
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
  • WENG Jiaju
    School of Basic Medical Science, Peking University, Beijing 100083, PR China School of Basic Medical Science, Peking University, Beijing 100083, PR China
  • ZHANG Haolin
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
  • LI Xiaonan
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
  • ZHANG Mengyuan
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
  • XU Meiyu
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
  • WENG Qiang
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan
  • WATANABE Gen
    Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
  • TAYA Kazuyoshi
    Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan

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  • Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (<i>Citellus dauricus brandt</i>) Ovary

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The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and Western blotting have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (α, βA and βB). In the breeding season ovary, all three subunits were present in granulosa cells, theca cells of antral follicles and interstitial cells, with the strongest immunostaining in granulosa cells. Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. In the nonbreeding season ovary, inhibin/activin α and βA subunits were weakly immunopositive in granulosa cells of early stage follicles, while βB subunit was undetectable. The expression level of inhibin/activin subunit proteins were generally higher in the ovaries of the breeding season, and then decreased to a relatively low level during the nonbreeding season. The dynamic expression of inhibin/activin subunits indicated that they might play important paracrine and/or autocrine roles during the seasonal folliculogenesis of the wild ground squirrel.

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