Differences in Apoptotic Status in the Bovine Placentome between Spontaneous and Induced Parturition
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- HIRAYAMA Hiroki
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- USHIZAWA Koichi
- Animal Physiology Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan Animal Physiology Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
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- TAKAHASHI Toru
- Animal Physiology Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan Animal Physiology Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
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- SAWAI Ken
- Department of Animal Science, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan Department of Animal Science, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
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- MORIYASU Satoru
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- KAGEYAMA Soichi
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- MIURA Ryotaro
- Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
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- MATSUI Motozumi
- Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
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- FUKUDA Shigeo
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- NAITO Akira
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- FUJII Takashi
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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- MINAMIHASHI Akira
- Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan
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抄録
We conducted this study to analyze apoptotic changes in the bovine placentome at spontaneous and induced parturition. Cows delivered i) after the administration of dexamethasone followed by prostaglandin F2α and estriol, ii) after the administration of prostaglandin F2α and estriol or iii) spontaneously. Prepartum changes in plasma progesterone and estradiol-17β concentrations were similar between spontaneous and induced parturition. Messenger RNA of BCL2-related protein A1 (BCL2A1), an antiapoptotic gene, was expressed by trophoblast binucleate cells and caruncular epithelial cells. Quantitative RT-PCR showed that the expression of BCL2A1 mRNA in cotyledonary and caruncular portions was significantly lower in spontaneous parturition than induced parturition. The expression of BCL2-associated X protein (BAX) mRNA, a proapoptotic gene, was significantly higher in cotyledons at spontaneous parturition than parturition induced without dexamethasone. Caspase-3 (CASP3) mRNA and pre-activated CASP3 protein were predominantly detected in caruncular epithelial cells regardless of how parturition proceeded. Activated CASP3 protein was found in trophoblast uninucleate cells and binucleate cells rather than caruncular epithelial cells. In spontaneous parturition, intense staining of activated CASP3 was detected in caruncular epithelial cells. Spontaneous and dexamethasone-induced parturition increased apoptotic cells in the placentome compared with parturition induced without dexamethasone. The number of binucleate cells was significantly decreased in spontaneous parturition. The present results suggest that although the clinical dose of dexamethasone induces apoptosis in the placentome at term, neither dexamethasone nor prostaglandin F2α evoke normal physiological changes in the placentome during delivery such as a change in the balance of apoptosis-related genes and disappearance of binucleate cells.
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 58 (5), 585-591, 2012
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282681313303424
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- NII論文ID
- 10031123304
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- NII書誌ID
- AA10936678
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- COI
- 1:STN:280:DC%2BC38jpt1eruw%3D%3D
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 024026212
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- PubMed
- 22785250
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可