Expression Pattern of Sulfated Glycoprotein-2 (SGP-2) mRNA in Rat Testes Exposed to Endocrine Disruptors
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- YON Jung-Min
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- KWAK Dong Hoon
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- CHO Young Kwang
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- LEE Se-Ra
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- JIN Yan
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- BAEK In-Jeoung
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- LEE Jeung Eun
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- NAHM Sang-Soep
- College of Veterinary Medicine, Konkuk University
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- CHOO Young-Kug
- Department of Biological Science, College of Natural Sciences, Wonkwang University
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- LEE Beom Jun
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- YUN Young Won
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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- NAM Sang-Yoon
- College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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Description
Sulfated glycoprotein-2 (SGP-2) is secreted in Sertoli cells and epididymal epithelial cells and plays important roles in the regulation of spermatogenesis and sperm maturation. To investigate whether endocrine disruptors affect spermatogenesis through an SGP-2-dependent mechanism, daily oral doses of testosterone (50, 200 and 1,000 μg/kg), flutamide (1, 5 and 25 mg/kg), ketoconazole (0.2, 1, 5 and 25 mg/kg), diethylhexylphthalate (10, 50 and 250 mg/kg), nonylphenol (10, 50, 100 and 250 mg/kg), octylphenol (10, 50 and 250 mg/kg), diethylstilbesterol (10, 20 and 40 μg/kg) or corn oil (control) were administered to 5 week-old, male Sprague-Dawley rats for 3 weeks. Following treatment with these endocrine disruptors, testicular expression of SGP-2 mRNA was analyzed using reverse transcription-polymerase chain reaction. Compared with the control, the lowest dose of testosterone (50 μg/kg/day) significantly increased expression of SGP-2 mRNA, whereas 200 and 1,000 μg/kg/day testosterone significantly decreased the expression (P<0.05). Flutamide, ketoconazole, diethylhexylphthalate, nonylphenol, octylphenol and diethylstilbesterol significantly decreased SGP-2 mRNA expression in testes at all doses studied, with the exception of 1 mg/kg/day flutamide (P<0.05). These results suggest that endocrine disruptors might decrease spermatogenesis in testes by decreasing expression of SGP-2 mRNA.<br>
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 53 (5), 1007-1013, 2007
The Society for Reproduction and Development
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Details 詳細情報について
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- CRID
- 1390282681313387776
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- NII Article ID
- 10019768682
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- NII Book ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 8965446
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed