Suppression of Progesterone-enhanced Hyperactivation in Hamster Spermatozoa by γ-aminobutyric Acid

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  • KON Hiroe
    Laboratory Animal Research Center, Dokkyo Medical University, Tochigi 321-0293, Japan
  • TAKEI Gen L.
    Department of Physiology, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan
  • FUJINOKI Masakatsu
    Department of Physiology, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan
  • SHINODA Motoo
    Laboratory Animal Research Center, Dokkyo Medical University, Tochigi 321-0293, Japan

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It has been recently shown that mammalian spermatozoa were hyperactivated by steroids, amines and amino acids. In the present study, we investigated whether hyperactivation of hamster sperm is regulated by progesterone (P) and γ-aminobutyric acid (GABA). Although sperm hyperactivation was enhanced by P, GABA significantly suppressed P-enhanced hyperactivation in a dose-dependent manner. Suppression of P-enhanced hyperactivation by GABA was significantly inhibited by an antagonist of the GABAA receptor (bicuculline). Moreover, P bound to the sperm head, and this binding was decreased by GABA. Because the concentrations of GABA and P change in association with the estrous cycle, these results suggest that GABA and P competitively regulate the enhancement of hyperactivation through the GABAA receptor.

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