STUDIES ON WATER AND ELECTROLYTE-REGULATING HORMONES

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  • HIRATA KIYOFUMI
    Department of Internal Medicine, School of Medicine Keio University
  • HAGIWARA TAKASHI
    Department of Internal Medicine, School of Medicine Keio University
  • KATO EIICHI
    Department of Internal Medicine, School of Medicine Keio University
  • ASANO SEIICHI
    Department of Internal Medicine, School of Medicine Keio University
  • AIZAWA TOYOZO
    Department of Internal Medicine, School of Medicine Keio University

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タイトル別名
  • I. PLASMA ANTIDIURETIC ACTIVITY AND URINARY SODIUM-RETAINING ACTIVITY IN PATIENTS WITH EDEMATOUS DISEASES

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説明

Both antidiuretic activity of the plasma and sodium-retaining activity of the urine from patients with edmatous diseases were assayed. The results obtained are as follows;<br>Both plsma antidiuretic activity and urinary sodium-retaining activity were increased in patients with so-called secondary hyperaldosteronism.<br>Some correlation between urinary sodium-retaining activity and sodium output was found in the limited groups of patients assayed, but no correlation was observed in patients with cirrhosis of the liver.<br>In bioassay of crude extracts of urine from some cases of non-edematous patients, the negative value, i.e. sodium-excreting activities were obtained.<br>On the basis of our findings, the roles of ADH and aldosterone in the pathogenesis of edema formation and the possibility of the presence of sodium-excreting hormones in human body were discussed.

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