Short-Term Hormone Release from Adult Female Rat Hypothalamic and Pituitary Explants is not Altered by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
-
- TREWIN Amanda Louise
- Department of Biology, University of Wisconsin-Platteville
-
- WOLLER Michael John
- Department of Biological Sciences, University of Wisconsin-Whitewater
-
- WIMPEE Barbara Ann Brown
- Department of Biological Sciences, University of Wisconsin-Milwaukee Great Lakes Water Institute, University of Wisconsin-Milwaukee
-
- CONLEY Lisa Kay
- Department of Biological Sciences, University of Wisconsin-Milwaukee Department of Natural Sciences, Milwaukee Area Technical College
-
- BALDRIDGE Monika Gabriella
- Department of Biological Sciences, University of Wisconsin-Milwaukee Department of Biology, Carroll College
-
- HUTZ Reinhold J.
- Department of Biological Sciences, University of Wisconsin-Milwaukee Great Lakes Water Institute, University of Wisconsin-Milwaukee
この論文をさがす
抄録
2, 3, 7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has adverse effects on reproduction, in part due to direct actions at the ovary. It is unclear whether effects are further mediated by glands that regulate ovarian function. We investigated whether effects of TCDD are mediated via the hypothalamic-pituitary axis. Hypothalamic and pituitary tissues were cultured in medium with and without TCDD. TCDD did not alter GnRH release from hypothalamic samples. It continued to be pulsatile with no differences in the average peak frequency, average peak amplitude, or baseline GnRH release. TCDD did not alter GnRH-induced release of gonadotropins from pituitary samples. There were no differences in average peak amplitude or baseline release. AhR, ARNT or ERα mRNA copy numbers in cultured pituitaries were not affected by TCDD. Our data suggest that TCDD effects on ovarian function are not mediated through the hypothalamic or pituitary release parameters tested in this study.<br>
収録刊行物
-
- Journal of Reproduction and Development
-
Journal of Reproduction and Development 53 (4), 765-775, 2007
公益社団法人 日本繁殖生物学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681314176768
-
- NII論文ID
- 10020003696
-
- NII書誌ID
- AA10936678
-
- ISSN
- 13484400
- 09168818
-
- NDL書誌ID
- 8882759
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可