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- SCHAMS Dieter
- Institut für Physiologie, Forschungszentrum für Milch und Lebensmittel Weihenstephan, Technische Universität München
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- BERISHA Bajram
- Institut für Physiologie, Forschungszentrum für Milch und Lebensmittel Weihenstephan, Technische Universität München
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説明
Angiogenesis, the development of the new capillaries by endothelial cell proliferation and outgrowth from pre-existing vessels, is one of the prominent features of early corpus luteum (CL). The process of angiogenesis is an important component of normal development and function of CL. Of the numerous promoters of angiogenesis and maintenance of new established capillaries that have been identified, the most important factors appear to be vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF). The biological effects of VEGF and FGF factor families are mediated by signaling through specific tyrosine kinase receptors. The VEGF, FGF and IGF family members in bovine CL are discussed with the literature available for large domestic animals. The highest expression for VEGF, VEGFR-2, FGF-2, FGFR, IGF-1, IGF-2 and IGFR1 were found during the early luteal phase (Ld 1-4) followed by a significant decrease afterwards. The VEGF and IGF-1 protein was localized predominantly in luteal cells. FGF-1 mRNA expression peaked (P<0.05) during mid-luteal stage and FGF-1 protein was localized in cytoplasm of luteal cells, but endothelial cells are always negative. FGF-2 protein during angiogenesis (d 1-5) was found in cytoplasm of endothelial cells and changed thereafter exclusively to the cytoplasm of luteal cells. In contrast, the IGF-2 protein is exclusively localized in pericytes and few endothelial cells. The results obtained (mainly in ruminant) suggest an important role of these growth factors for angiogenesis and furthermore for maintenance and function of the bovine corpus luteum.
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 48 (3), 233-242, 2002
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282681314464000
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- NII論文ID
- 10026616508
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- NII書誌ID
- AA10936678
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- COI
- 1:CAS:528:DC%2BD38XmvFSmtrw%3D
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 6206130
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可