A unique mechanism regulating gene expression in 1-cell embryos
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- YAMAMOTO Ryoma
- Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan
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- AOKI Fugaku
- Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan
Bibliographic Information
- Other Title
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- Opinions and Hypotheses : A unique mechanism regulating gene expression in 1-cell embryos
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Description
<p> After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.</p>
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 63 (1), 9-11, 2017
The Society for Reproduction and Development
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Keywords
Details 詳細情報について
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- CRID
- 1390282681314858752
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- NII Article ID
- 130005332263
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- NII Book ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 027985239
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- PubMed
- 27867162
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed