A unique mechanism regulating gene expression in 1-cell embryos

DOI Web Site Web Site PubMed 5 Citations 18 References Open Access
  • YAMAMOTO Ryoma
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan
  • AOKI Fugaku
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan

Bibliographic Information

Other Title
  • Opinions and Hypotheses : A unique mechanism regulating gene expression in 1-cell embryos

Search this article

Description

<p> After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.</p>

Journal

Citations (5)*help

See more

References(18)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top