Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 6 Years after Complete Response to IFN Treatment: A Case Report and Review of the Literature.

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  • Aiba Masaaki
    Department of Surgery, National Sanatarium Nishi-Gunma Hospital
  • Makita Fujio
    Department of Surgery, National Sanatarium Nishi-Gunma Hospital
  • Muraoka Masato
    Department of Surgery, National Sanatarium Nishi-Gunma Hospital
  • Kaneko Mieko
    Department of Internal Medicine, Ota General Hospital
  • Matsumoto Tatsuhiko
    Department of Gastroenterology, National Sanatarium, Nishi-Gunma Hospital
  • Matsuzaki Yutaka
    Department of Gastroenterology, National Sanatarium, Nishi-Gunma Hospital
  • Takeyoshi Izumi
    Second Department of Surgery, Gunma University School of Medicine
  • Ohwada Susumu
    Second Department of Surgery, Gunma University School of Medicine
  • Morishita Yasuo
    Second Department of Surgery, Gunma University School of Medicine

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Other Title
  • インターフェロン療法著効後６年目に肝細胞癌が認められたＣ型慢性肝炎の１切除例　　本邦報告例も含めて
  • インターフェロン リョウホウ チョコウゴ 6ネンメ ニ カン サイボウ ガン ガ ミトメラレタ Cガタ マンセイ カンエン ノ 1 セツジョレイ : ホンポウ ホウコクレイ モ フクメテ

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Abstract

A 60-year-old man diagnosed with chronic active hepatitis with hepatitis C virus infection was treated with interferon (IFN)-alpha. A successful response was obtained with normalization of serum alanine aminotransferase (ALT) and the disappearance of serum hepatitis C virus-ribonucleic acid (HCV-RNA). Serum ALT remained within normal levels and serum HCV-RNA was not detected during observation. Six years later, the level of serum PIVKA-II increased and hepatocellular carcinoma (HCC) was detected by CT examination. Partial hepatectomy of segment 4 was performed following transcatheter arterial embolization. Histological examination of the surgical specimen showed moderately differentiated HCC, and chronic hepatitis, bridging fibrosis with mild activity of necro-inflammatory reaction. These results suggest that even patients with chronic hepatitis C infection who show complete response to interferon therapy should be followed up at 3 to 6 month intervals associated with examinations for serum tumor markers and ultrasonographic screening for the potential development of HCC.

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